About Ataxin-1-like
Ataxin-1-like (ATXN1L) is a protein
from Homo sapiens identified by UniProt accession
P0C7T5, 689 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Ataxin-1-like |
|---|
| UniProt accession | P0C7T5 |
|---|
| Gene | ATXN1L |
|---|
| Organism | Homo sapiens |
|---|
| Length | 689 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (59)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- cigarettes per day measurement · score 0.13
- waist circumference · score 0.13
- reticulocyte count · score 0.11
- body mass index · score 0.11
- red blood cell density measurement · score 0.10
- fat body mass · score 0.10
- risky sexual behaviour measurement · score 0.09
- reticulocyte measurement · score 0.09
- lean body mass · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C7T5-F1 | alphafold | PREDICTED | 50.46 | — |
Amino-acid sequence (689 residues)
MKPVHERSQE CLPPKKRDLP VTSEDMGRTT SCSTNHTPSS DASEWSRGVV VAGQSQAGAR VSLGGDGAEA ITGLTVDQYG MLYKVAVPPA TFSPTGLPSV VNMSPLPPTF NVASSLIQHP GIHYPPLHYA QLPSTSLQFI GSPYSLPYAV PPNFLPSPLL SPSANLATSH LPHFVPYASL LAEGATPPPQ APSPAHSFNK APSATSPSGQ LPHHSSTQPL DLAPGRMPIY YQMSRLPAGY TLHETPPAGA SPVLTPQESQ SALEAAAANG GQRPRERNLV RRESEALDSP NSKGEGQGLV PVVECVVDGQ LFSGSQTPRV EVAAPAHRGT PDTDLEVQRV VGALASQDYR VVAAQRKEEP SPLNLSHHTP DHQGEGRGSA RNPAELAEKS QARGFYPQSH QEPVKHRPLP KAMVVANGNL VPTGTDSGLL PVGSEILVAS SLDVQARATF PDKEPTPPPI TSSHLPSHFM KGAIIQLATG ELKRVEDLQT QDFVRSAEVS GGLKIDSSTV VDIQESQWPG FVMLHFVVGE QQSKVSIEVP PEHPFFVYGQ GWSSCSPGRT TQLFSLPCHR LQVGDVCISI SLQSLNSNSV SQASCAPPSQ LGPPRERPER TVLGSRELCD SEGKSQPAGE GSRVVEPSQP ESGAQACWPA PSFQRYSMQG EEARAALLRP SFIPQEVKLS IEGRSNAGK
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