About DDB1- and CUL4-associated factor 8-like protein 2
DDB1- and CUL4-associated factor 8-like protein 2 (DCAF8L2) is a protein
from Homo sapiens identified by UniProt accession
P0C7V8, 631 residues long.
MolForge cross-references it against 0 known binders and
3 disease associations.
Target properties
| Protein name | DDB1- and CUL4-associated factor 8-like protein 2 |
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| UniProt accession | P0C7V8 |
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| Gene | DCAF8L2 |
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| Organism | Homo sapiens |
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| Length | 631 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (3)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- body weight · score 0.02
- neuropathy · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0C7V8-F1 | alphafold | PREDICTED | 70.28 | — |
Amino-acid sequence (631 residues)
MSHQEGSTDG LPDLGTESLF SSPEEQSGAV AATEASSDID IATSELSVTV TGDGSDSRDG GFPNDASTEN RSSDQESASE DIELESLEDF EHFLMSGESL FHYPLVGEEE TEREEEDEEI QEEGGEEEEE EEEEEEEEEE EEEEEEEQPR AGPQGSGGNH EQYSLEEDQA LEEWVSSETS ALPRPRWQVV TALHQRQLGS RPRFVYEACG ARAFVQRFRL QYRLADHVGC VNTVHFNQRG TRLASSGDDL KVIVWDWVRQ RPVLNFESGH TNNVFQAKFL PNCGDSTLAM CARDGQVRVA ELINASYFNN TKCVAQHRGP AHKLALEPDS PYKFLTSGED AVVFTIDLRQ DRPASKVVVT RENDKKVGLY TITVNPANTY QFAVGGQDQF VRIYDQRKID KKENNGVLKK FTPHHLVNCD FPTNITCVVY SHDGTELLAS YNDDDIYLFN SSHSDGAQYS KRFKGHRNNT TVKGVNFYGP RSEFVVSGSD CGHIFFWEKS SCQIIQFLKG SREGTINCLE PHPYLPVLAC SGLDHDVKIW TPTAKAATEL TGLKKVIKKN KWERDEDSLH HGSLFDQYML WFLLRHVTQR GRHQDWRSGE AEFPDEESDE SSSTSETSEE EVQDRVQCMP S
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