Myocardial zonula adherens protein (MYZAP)

About Myocardial zonula adherens protein

Myocardial zonula adherens protein (MYZAP) is a protein from Homo sapiens identified by UniProt accession P0CAP1, 466 residues long. MolForge cross-references it against 0 known binders and 76 disease associations.

Target properties

Protein name	Myocardial zonula adherens protein
UniProt accession	P0CAP1
Gene	MYZAP
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (76)

Diseases linked to this target (Open Targets).

cardiac arrhythmia · score 0.41
atrial fibrillation · score 0.34
chronic obstructive pulmonary disease · score 0.33
DNA methylation · score 0.33
dilated cardiomyopathy · score 0.31
high density lipoprotein particle size measurement · score 0.29
triglyceride measurement · score 0.28
antisocial behaviour measurement · score 0.27
substance abuse · score 0.27
high density lipoprotein cholesterol measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0CAP1-F1	alphafold	PREDICTED	77.22	—

Amino-acid sequence (466 residues)

MLRSTSTVTL LSGGAARTPG APSRRANVCR LRLTVPPESP VPEQCEKKIE RKEQLLDLSN GEPTRKLPQG VVYGVVRRSD QNQQKEMVVY GWSTSQLKEE MNYIKDVRAT LEKVRKRMYG DYDEMRQKIR QLTQELSVSH AQQEYLENHI QTQSSALDRF NAMNSALASD SIGLQKTLVD VTLENSNIKD QIRNLQQTYE ASMDKLREKQ RQLEVAQVEN QLLKMKVESS QEANAEVMRE MTKKLYSQYE EKLQEEQRKH SAEKEALLEE TNSFLKAIEE ANKKMQAAEI SLEEKDQRIG ELDRLIERME KERHQLQLQL LEHETEMSGE LTDSDKERYQ QLEEASASLR ERIRHLDDMV HCQQKKVKQM VEEIESLKKK LQQKQLLILQ LLEKISFLEG ENNELQSRLD YLTETQAKTE VETREIGVGC DLLPSQTGRT REIVMPSRNY TPYTRVLELT MKKTLT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards