About DNA-directed RNA polymerase II subunit GRINL1A
DNA-directed RNA polymerase II subunit GRINL1A (POLR2M) is a protein
from Homo sapiens identified by UniProt accession
P0CAP2, 368 residues long.
MolForge cross-references it against 0 known binders and
60 disease associations.
Target properties
| Protein name | DNA-directed RNA polymerase II subunit GRINL1A |
|---|
| UniProt accession | P0CAP2 |
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| Gene | POLR2M |
|---|
| Organism | Homo sapiens |
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| Length | 368 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (60)
Diseases linked to this target (Open Targets).
- low density lipoprotein particle size measurement · score 0.31
- exercise test · score 0.26
- DNA methylation · score 0.19
- genetic disorder · score 0.19
- neurodegenerative disease · score 0.14
- neuroimaging measurement · score 0.05
- Combined hyperlipidemia · score 0.04
- cholesterol-ester transfer protein deficiency · score 0.04
- tooth agenesis · score 0.04
- Hypomaturation amelogenesis imperfecta · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0CAP2-F1 | alphafold | PREDICTED | 66.16 | — |
Amino-acid sequence (368 residues)
MCSLPRGFEP QAPEDLAQRS LVELREMLKR QERLLRNEKF ICKLPDKGKK IFDSFAKLKA AIAECEEVRR KSELFNPVSL DCKLRQKAIA EVDVGTDKAQ NSDPILDTSS LVPGCSSVDN IKSSQTSQNQ GLGRPTLEGD EETSEVEYTV NKGPASSNRD RVPPSSEASE HHPRHRVSSQ AEDTSSSFDN LFIDRLQRIT IADQGEQQSE ENASTKNLTG LSSGTEKKPH YMEVLEMRAK NPVPQLRKFK TNVLPFRQND SSSHCQKSGS PISSEERRRR DKQHLDDITA ARLLPLHHMP TQLLSIEESL ALQKQQKQNY EEMQAKLAAQ KLAERLNIKM RSYNPEGESS GRYREVRDED DDWSSDEF
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