Golgi pH regulator B (GPR89B)

About Golgi pH regulator B

Golgi pH regulator B (GPR89B) is a protein from Homo sapiens identified by UniProt accession P0CG08, 455 residues long. MolForge cross-references it against 0 known binders and 27 disease associations.

Target properties

Protein name	Golgi pH regulator B
UniProt accession	P0CG08
Gene	GPR89B
Organism	Homo sapiens
Length	455 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (27)

Diseases linked to this target (Open Targets).

urate measurement · score 0.15
hemoglobin measurement · score 0.05
Okt4 epitope deficiency · score 0.05
hematocrit · score 0.05
erythrocyte count · score 0.05
red blood cell density measurement · score 0.04
atrial fibrillation · score 0.04
mean corpuscular hemoglobin concentration · score 0.04
combined immunodeficiency with skin granulomas · score 0.03
Peptic ulcer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0CG08-F1	alphafold	PREDICTED	82.51	—

Amino-acid sequence (455 residues)

MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE KQMAP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards