About Decreased expression in renal and prostate cancer protein
Decreased expression in renal and prostate cancer protein (DERPC) is a protein
from Homo sapiens identified by UniProt accession
P0CG12, 524 residues long.
MolForge cross-references it against 0 known binders and
14 disease associations.
Target properties
| Protein name | Decreased expression in renal and prostate cancer protein |
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| UniProt accession | P0CG12 |
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| Gene | DERPC |
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| Organism | Homo sapiens |
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| Length | 524 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (14)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.09
- body height · score 0.07
- heel bone mineral density · score 0.06
- IGF-1 measurement · score 0.04
- body mass index · score 0.03
- sitting height measurement · score 0.03
- alcohol consumption measurement · score 0.03
- brain measurement · score 0.02
- neuroimaging measurement · score 0.02
- high density lipoprotein cholesterol measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0CG12-F1 | alphafold | PREDICTED | 46.14 | — |
Amino-acid sequence (524 residues)
MKEPRIFPRE RPTPWTRAPL PPRGRLDGSL GPQGGPVLNT GHPLGVNSDP FLMAAGSLGG NLTPFPRNPS PFPASSGSLA SNPAPFPAGA RDPSMASFPR GMNPTGTGAV SFPRPGGLLG PGPGPGPTLN PRTGALPGPG PLSNPRLGGL PGPGPMSNPR AGGLLGAGPD PRGGGPMGPG SGPNLRAGVL LTSGNGPPNP RPVGLGPGPN PNLRSGFLGT NPAPRSGVFP GPGLGPNPRP SGLGPGPNLD ARAGGLLGTG SGLNLRMAGP QGLDLAPILR AAGLLGANSA SFSQASGNMG TSPSSMARVP GPMGPNSGPS SRGIGLPGPN PSPMSRAPGP IGPNSAHFSR PVGPMGVNAN PFPRGAGSSA FSQSSGTLAS NPATFQRSAG LQGSNPTIFP RASGPLGPNP ANFPRATGLQ GPSPTTFPRS TGPLGPGQVT FPRPAAGHLG PSPAGPVGIN PAPFTRPTGT LGLNPASFPR MNGPAGKSFV PFPRVGSLPG TNPAAFPRPG GPMAAMYPNG MLPP
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