About Proline-rich protein 35
Proline-rich protein 35 (PRR35) is a protein
from Homo sapiens identified by UniProt accession
P0CG20, 571 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Proline-rich protein 35 |
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| UniProt accession | P0CG20 |
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| Gene | PRR35 |
|---|
| Organism | Homo sapiens |
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| Length | 571 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (23)
Diseases linked to this target (Open Targets).
- erythrocyte count · score 0.09
- age-related macular degeneration · score 0.08
- X-linked retinal dysplasia · score 0.08
- retinitis pigmentosa · score 0.07
- choroidal dystrophy, central areolar, 1 · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- severe early-childhood-onset retinal dystrophy · score 0.06
- age related macular degeneration 7 · score 0.06
- age related macular degeneration 4 · score 0.06
- age related macular degeneration 11 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0CG20-F1 | alphafold | PREDICTED | 49.35 | — |
Amino-acid sequence (571 residues)
MSREAGSCRV GTGARARSRK PKKPHYIPRP WGKPYNYKCF QCPFTCLEKS HLYNHMKYSL CKDSLSLLLD SPDWACRRGS TTPRPHAPTP DRPGESDPGR QPQGARPTGA APAPDLVVAD IHSLHCGGGP KSRAKGSPGP PPPVARATRK GPGPSGLLPE SWKPGMGGDP RGVGAGDMAS AGPEGSVPCY PPPAPGEFPE AHSLHLSLLG VNYPLSPGLF SYLGPSLAAA AHVPFLASAS PLLPPATAFP AVQPPQRPTP APRLYYPLLL EHTLGLPAGK AALAKAPVSP RSPSGTPAPG LLKVPVPGLG PWPRVTPRDP GQEGELERAA QSDPRRRLSL GSRLELPKAS PSLTRFCSRS SLPTGSSVML WPEDGDPGGP ETPGPEGPLP LQPRGPVPGS PEHVGEDLTR ALGDYARVEQ RLGQLGPAGG LAPRPLREQL GKIRLELLTI HQALEQAVRP PDAPLDLSVK RAPAKGPQAL GEAWGRPELG PVLTGGTPEP PGMLGPAAPQ PFSGHTTKCE ADSSVPPPGL PLAAPDDPVI PGSGWGTCVA TRSSQTPEAV CGLQSPQGAE V
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