NHL-repeat-containing protein 4 (NHLRC4)

About NHL-repeat-containing protein 4

NHL-repeat-containing protein 4 (NHLRC4) is a protein from Homo sapiens identified by UniProt accession P0CG21, 123 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	NHL-repeat-containing protein 4
UniProt accession	P0CG21
Gene	NHLRC4
Organism	Homo sapiens
Length	123 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.27
mean corpuscular volume · score 0.05
mean corpuscular hemoglobin · score 0.05
erythrocyte count · score 0.04
Red cell distribution width · score 0.03
mean reticulocyte volume · score 0.03
mean corpuscular hemoglobin concentration · score 0.03
reticulocyte count · score 0.03
cortical surface area measurement · score 0.02
heel bone mineral density · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0CG21-F1	alphafold	PREDICTED	93.98	—

Amino-acid sequence (123 residues)

MLGLEGPCWV GPGPDGGLAV SEEFGDVRLF GSARQPLGSL GGWTGHTFGC PAGICSNSEG NVIVADEQRR QVTLFPRAGP PICLVSEGLG QPLGVACAPQ GQLLVADAKD NSIKVYQGLK ELA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards