Glutathione S-transferase theta-2B (GSTT2B)

About Glutathione S-transferase theta-2B

Glutathione S-transferase theta-2B (GSTT2B) is a protein from Homo sapiens identified by UniProt accession P0CG30, 244 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Glutathione S-transferase theta-2B
UniProt accession	P0CG30
Gene	GSTT2B
Organism	Homo sapiens
Length	244 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
sex hormone-binding globulin measurement · score 0.28
megalencephalic leukoencephalopathy with subcortical cysts · score 0.27
serum gamma-glutamyl transferase measurement · score 0.21
neutrophil count · score 0.20
serum alanine aminotransferase measurement · score 0.18
testosterone measurement · score 0.18
alkaline phosphatase measurement · score 0.18
protein measurement · score 0.17
myeloid white cell count · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0CG30-F1	alphafold	PREDICTED	98.10	—

Amino-acid sequence (244 residues)

MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG WHADCIRGTF GIPLWVQVLG PLIGVQVPEE KVERNRTAMD QALQWLEDKF LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards