About cTAGE family member 8
cTAGE family member 8 (CTAGE8) is a protein
from Homo sapiens identified by UniProt accession
P0CG41, 777 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | cTAGE family member 8 |
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| UniProt accession | P0CG41 |
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| Gene | CTAGE8 |
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| Organism | Homo sapiens |
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| Length | 777 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- hypertriglyceridemia 2 · score 0.06
- cholesterol-ester transfer protein deficiency · score 0.05
- pancreatic triacylglycerol lipase deficiency · score 0.05
- homozygous familial hypercholesterolemia · score 0.04
- Combined hyperlipidemia · score 0.04
- thyroid hormone metabolism, abnormal, 2 · score 0.04
- Fish-eye disease · score 0.04
- sitosterolemia · score 0.04
- hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.04
- hypercholesterolemia, autosomal dominant, 3 · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0CG41-F1 | alphafold | PREDICTED | 68.61 | — |
Amino-acid sequence (777 residues)
MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGQVSE LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE EKISRATEGL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF
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