About Polyubiquitin-B
Polyubiquitin-B (UBB) is a protein
from Homo sapiens identified by UniProt accession
P0CG47, 229 residues long.
MolForge cross-references it against 0 known binders and
282 disease associations.
Target properties
| Protein name | Polyubiquitin-B |
|---|
| UniProt accession | P0CG47 |
|---|
| Gene | UBB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 229 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (282)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.57
- cancer · score 0.53
- listeriosis · score 0.53
- tuberculosis · score 0.46
- cystic fibrosis · score 0.46
- severe acute respiratory syndrome · score 0.46
- COVID-19 · score 0.37
- diabetes mellitus · score 0.18
- age-related macular degeneration · score 0.09
- retinitis pigmentosa · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0CG47-F1 | alphafold | PREDICTED | 93.41 | — |
Amino-acid sequence (229 residues)
MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI FAGKQLEDGR TLSDYNIQKE STLHLVLRLR GGMQIFVKTL TGKTITLEVE PSDTIENVKA KIQDKEGIPP DQQRLIFAGK QLEDGRTLSD YNIQKESTLH LVLRLRGGC
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