Tripartite motif-containing protein 49 (TRIM49)

About Tripartite motif-containing protein 49

Tripartite motif-containing protein 49 (TRIM49) is a protein from Homo sapiens identified by UniProt accession P0CI25, 452 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 49
UniProt accession	P0CI25
Gene	TRIM49
Organism	Homo sapiens
Length	452 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

homocysteine measurement · score 0.04
adolescent idiopathic scoliosis · score 0.03
pulse pressure measurement · score 0.03
sunburn · score 0.03
soluble triggering receptor expressed on myeloid cells 2 measurement · score 0.03
hemolytic anemia · score 0.03
hair colour measurement · score 0.02
forced expiratory volume · score 0.02
HIV-1 infection · score 0.01
Sjogren syndrome · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0CI25-F1	alphafold	PREDICTED	85.44	—

Amino-acid sequence (452 residues)

MNSGILQVFQ GELICPLCMN YFIDPVTIDC GHSFCRPCFY LNWQDIPFLV QCSECTKSTE QINLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK KIFCEVDRSL LCLLCSSSQE HRYHRHRPIE WAAEEHREKL LQKMQSLWEK ACENHRNLNV ETTRTRCWKD YVNLRLEAIR AEYQKMPAFH HEEEKHNLEM LKKKGKEIFH RLHLSKAKMA HRMEILRGMY EELNEMCHKP DVELLQAFGD ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANNDI FLYEILRSMC IGCDHQDVPY FTATPRSFLA WGVQTFTSGK YYWEVHVGDS WNWAFGVCNM YRKEKNQNEK IDGKAGLFLL GCVKNDIQCS LFTTSPLMLQ YIPKPTSRVG LFLDCEAKTV SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI HF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards