A-kinase anchor protein inhibitor 1 (AKAIN1)

About A-kinase anchor protein inhibitor 1

A-kinase anchor protein inhibitor 1 (AKAIN1) is a protein from Homo sapiens identified by UniProt accession P0CW23, 69 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	A-kinase anchor protein inhibitor 1
UniProt accession	P0CW23
Gene	AKAIN1
Organism	Homo sapiens
Length	69 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

chronotype measurement · score 0.49
body height · score 0.41
adolescent idiopathic scoliosis · score 0.34
arterial stiffness measurement · score 0.33
type 2 diabetes mellitus · score 0.14
smoking behavior · score 0.12
intelligence · score 0.05
self reported educational attainment · score 0.04
central nervous system cancer · score 0.04
IGF-1 measurement · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0CW23-F1	alphafold	PREDICTED	75.76	—

Amino-acid sequence (69 residues)

MVFAPGEKPG NEPEEVKLQN ASKQIVQNAI LQAVQQVSQE SQRREERISD NRDHIQLGVG ELTKKHEKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards