About Coiled-coil domain-containing protein 166
Coiled-coil domain-containing protein 166 (CCDC166) is a protein
from Homo sapiens identified by UniProt accession
P0CW27, 439 residues long.
MolForge cross-references it against 0 known binders and
6 disease associations.
Target properties
| Protein name | Coiled-coil domain-containing protein 166 |
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| UniProt accession | P0CW27 |
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| Gene | CCDC166 |
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| Organism | Homo sapiens |
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| Length | 439 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (6)
Diseases linked to this target (Open Targets).
- appendicular lean mass · score 0.06
- deafness · score 0.05
- lean body mass · score 0.03
- pulmonary fibrosis and/or bone marrow failure syndrome, telomere-related, 9 · score 0.03
- cancer · score 0.00
- signet ring cell carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0CW27-F1 | alphafold | PREDICTED | 70.92 | — |
Amino-acid sequence (439 residues)
MAPKKKRGPS AGSQPGGAAA AGAEQPLSER AQYLQREHAL LSEQLDTCEE SVDQVLRENA FLDREALRLR EENRLYASYV SARAQRCAKA IVRLDEQNRV DLAQIHWQRA ELASLYHGRE DGVRAQLLEM EARAAQMAQQ VQELQPYKVL QLEQLARIRA LERELLHMRV EHTQLLHRVK RRFLEDKAAF EREARQRVQS LARRAEREAV RALVAHTQAI KADNGRLRQE LLLLLRRTQL LHHTRRQLLE QREQLHREHE DTRDLARVHG WLRRGPGGPP LWERPAFSQP TSRPGSLAAP ISPSRAASQT PSVVPSRAAP RASSVVPSRE ASRVPSLVLS SMDSRVPSLA TSKVGSRMPS LTASRAGSRA LSLVQSLEGS GISSGSSPRV SSQDTLRSTK SGPKLLSGLS RDRDPALLPP QSEDSVNAEA AAEASPGRA
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