About Trafficking protein particle complex subunit 2
Trafficking protein particle complex subunit 2 (TRAPPC2) is a protein
from Homo sapiens identified by UniProt accession
P0DI81, 140 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Trafficking protein particle complex subunit 2 |
|---|
| UniProt accession | P0DI81 |
|---|
| Gene | TRAPPC2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 140 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (49)
Diseases linked to this target (Open Targets).
- spondyloepiphyseal dysplasia tarda · score 0.74
- spondyloepiphyseal dysplasia tarda, X-linked · score 0.66
- genetic disorder · score 0.37
- hereditary spastic paraplegia 4 · score 0.34
- Autosomal dominant spastic paraplegia type 4 · score 0.34
- connective tissue disease · score 0.30
- neurodegenerative disease · score 0.27
- spondyloepiphyseal dysplasia congenita · score 0.17
- breast adenocarcinoma · score 0.10
- snowflake vitreoretinal degeneration · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DI81-F1 | alphafold | PREDICTED | 92.12 | — |
Amino-acid sequence (140 residues)
MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY LKTVDKFNEW FVSAFVTAGH MRFIMLHDIR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP IRSSAFDRKV QFLGKKHLLS
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