About RANBP2-like and GRIP domain-containing protein 2
RANBP2-like and GRIP domain-containing protein 2 (RGPD2) is a protein
from Homo sapiens identified by UniProt accession
P0DJD1, 1756 residues long.
MolForge cross-references it against 0 known binders and
55 disease associations.
Target properties
| Protein name | RANBP2-like and GRIP domain-containing protein 2 |
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| UniProt accession | P0DJD1 |
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| Gene | RGPD2 |
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| Organism | Homo sapiens |
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| Length | 1756 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (55)
Diseases linked to this target (Open Targets).
- mitochondrial heteroplasmy measurement · score 0.12
- isolated congenital hypogonadotropic hypogonadism · score 0.06
- Testicular regression syndrome · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
- azoospermia · score 0.06
- 46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency · score 0.06
- myofibromatosis, infantile, 1 · score 0.06
- BAP1-related tumor predisposition syndrome · score 0.06
- tumor predisposition syndrome 2 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DJD1-F1 | alphafold | PREDICTED | 65.33 | — |
Amino-acid sequence (1756 residues)
MRRSKAYGER YLASVQGSAP SPGKKLRGFY FAKLYYEAKE YDLAKKYVCT YLSVQERDPR AHRFLGLLYE LEENTEKAVE CYRRSLELNP PQKDLVLKIA ELLCKNDVTD GRAKYWVERA AKLFPGSPAI YKLKEHLLDC EGEDGWNKLF DWIQSELYVR PDDVHMNIRL VELYRSNKRL KDAVARCHEA ERNIALRSSL EWNSCVVQTL KEYLESLQCL ESDKSDWRAT NTDLLLAYAN LMLLTLSTRD VQESRELLES FDSALQSAKS SLGGNDELSA TFLEMKGHFY MHAGSLLLKM GQHGNNVQWQ ALSELAALCY VIAFQVPRPK IKLIKGEAGQ NLLEMMACDR LSQSGHMLLN LSRGKQDFLK EVVETFANKS GQSVLYNALF SSQSSKDTSF LGSDDIGNID VQEPELEDLA RYDVGAIQAH NGSLQHLTWL GLQWNSLPAL PGIRKWLKQL FHHLPQETSR LETNAPESIC ILDLEVFLLG VVYTSHLQLK EKCNSHHSSY QPLCLPLPVC KRLCTERQKS WWDAVCTLIH RKAVPGNSAE LRLVVQHEIN TLRAQEKHGL QPALLVHWAK CLQKMGRGLN SSYDQQEYIG RSVHYWKKVL PLLKIIKKNS IPEPIDPLFK HFHSVDIQAS EIVEYEEDAH ITFAILDAVH GNIEDAVTAF ESIKSVVSYW NLALIFHRKA EDIENDAVFP EEQEECKNYL RKTRDYLIKI IDDSDSNLSV VKKLPVPLES VKEMLKSVMQ ELEDYSEGGP LYKNGSLRNA DSEIKHSTPS PTKYSLSPSK SYKYSPKTPP RWAEDQNSLR KMICQEVKAI TKLNSSKSAS RHRWPTENYG PDSVPDGYQG SQTFHGAPLT VATTGPSVYY SQSPAYNSQY LLRPAANVTP TKGSSNTEFK STKEGFSIAV SADGFKFGIS EPGNQEKKSE KPLENDTGFQ AQDISGQKNG RGVIFGQTSS TFTFADVAKS TSGEGFQFGK KDPNFKGFSG AGEKLFSSQC GKMANKANTS GDFEKDDDAC KTEDSDDIHF EPVVQMPEKV ELVTGEEGEK VLYSQGVKLF RFDAEISQWK ERGLGNLKIL KNEVNGKPRM LMRRDQVLKV CANHWITTTM NLKPLSGSDR AWMWLASDFS DGDAKLERLA AQFKTPELAE EFKQKFEECQ RLLLDIPLQT PHKLVDTGRA AKLIQRAEEM KSGLKDFKTF LTNDQTKVTE EENKGSGTGA AGASDTTIKP NPENTGPTLE WDNYDLREDA LDDNVSSSSV HDSPLASSPV RKNIFRFDES TTGFNFSFKS ALSLSKSPAK LNQSGTSVGT DEESDVTQEE ERDGQYFEPV VPLPDLVEVS SGEENEQVVF SHMAELYRYD KDVGQWKERG IGDIKILQNY DNKQVRIVMR RDQVLKLCAN HRITPDMSLQ NMKGTERVWV WTACDFADGE RKVEHLAVRF KLQDVADSFK KIFDEAKTAQ EKDSLITPHV SRSSTPRESP CGKIAVAVLE ETTRERTDVI QGDDVADAAS EVEVSSTSET TTKAVVSPPK FVFGSESVKR IFSSEKSNPF AFGNSSATGS LFGFSFNAPL KSNDSETSSV AQSGSESKVE PKKCELSKNS DIEQSSDSKV KNLSASFPME ESSINYTFKT PEKEPPLWHA EFTKEELVQK LSSTTKSADQ LNGLLRETEA TSAVLMEQIK LLKSEIRRLE RNQEESAANV EHLKNVLLQF IFLKPGSERE SLLPVINTML QLSPEEKGKL AAVAQGLQET SIPKKK
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