About Pepsin A-4
Pepsin A-4 (PGA4) is a protein
from Homo sapiens identified by UniProt accession
P0DJD7, 388 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Pepsin A-4 |
|---|
| UniProt accession | P0DJD7 |
|---|
| Gene | PGA4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 388 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (30)
Diseases linked to this target (Open Targets).
- gastric carcinoma · score 0.06
- total blood protein measurement · score 0.05
- serum albumin measurement · score 0.04
- body height · score 0.03
- cancer · score 0.02
- gonorrhea · score 0.01
- infect · score 0.01
- infection · score 0.01
- chronic lung allograft dysfunction · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DJD7-F1 | alphafold | PREDICTED | 91.16 | — |
Amino-acid sequence (388 residues)
MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DQSGSVVIFG GIDSSYYTGS LNWVPVTVEG YWQITVDSIT MNGEAIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNLPTESGEL WILGDVFIRQ YFTVFDRANN QVGLAPVA
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