Pepsin A-3 (PGA3)

About Pepsin A-3

Pepsin A-3 (PGA3) is a protein from Homo sapiens identified by UniProt accession P0DJD8, 388 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	Pepsin A-3
UniProt accession	P0DJD8
Gene	PGA3
Organism	Homo sapiens
Length	388 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

serum albumin measurement · score 0.22
total blood protein measurement · score 0.18
blood protein measurement · score 0.18
cutaneous melanoma · score 0.17
gastric carcinoma · score 0.05
esophageal adenocarcinoma · score 0.03
red blood cell density measurement · score 0.03
hematocrit · score 0.02
multiple sclerosis · score 0.02
cancer · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DJD8-F1	alphafold	PREDICTED	91.17	—

Amino-acid sequence (388 residues)

MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWKAP TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DQSGSVVIFG GIDSSYYTGS LNWVPVTVEG YWQITVDSIT MNGEAIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNLPTESGEL WILGDVFIRQ YFTVFDRANN QVGLAPVA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards