About Pepsin A-5
Pepsin A-5 (PGA5) is a protein
from Homo sapiens identified by UniProt accession
P0DJD9, 388 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Pepsin A-5 |
|---|
| UniProt accession | P0DJD9 |
|---|
| Gene | PGA5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 388 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (46)
Diseases linked to this target (Open Targets).
- duodenal ulcer · score 0.56
- gastroesophageal reflux disease · score 0.46
- Peptic ulcer · score 0.46
- chronic gastritis · score 0.37
- proctitis · score 0.37
- dyspepsia · score 0.37
- cutaneous melanoma · score 0.17
- pancreatic adenocarcinoma · score 0.16
- Esophagitis · score 0.07
- body height · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DJD9-F1 | alphafold | PREDICTED | 91.28 | — |
Amino-acid sequence (388 residues)
MKWLLLLGLV ALSECIMYKV PLIRKKSLRR TLSERGLLKD FLKKHNLNPA RKYFPQWEAP TLVDEQPLEN YLDMEYFGTI GIGTPAQDFT VVFDTGSSNL WVPSVYCSSL ACTNHNRFNP EDSSTYQSTS ETVSITYGTG SMTGILGYDT VQVGGISDTN QIFGLSETEP GSFLYYAPFD GILGLAYPSI SSSGATPVFD NIWNQGLVSQ DLFSVYLSAD DKSGSVVIFG GIDSSYYTGS LNWVPVTVEG YWQITVDSIT MNGETIACAE GCQAIVDTGT SLLTGPTSPI ANIQSDIGAS ENSDGDMVVS CSAISSLPDI VFTINGVQYP VPPSAYILQS EGSCISGFQG MNVPTESGEL WILGDVFIRQ YFTVFDRANN QVGLAPVA
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