Serum amyloid A-1 protein (SAA1)

About Serum amyloid A-1 protein

Serum amyloid A-1 protein (SAA1) is a protein from Homo sapiens identified by UniProt accession P0DJI8, 122 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.

Target properties

Protein name	Serum amyloid A-1 protein
UniProt accession	P0DJI8
Gene	SAA1
Organism	Homo sapiens
Length	122 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (278)

Diseases linked to this target (Open Targets).

AL amyloidosis · score 0.46
serum amyloid A-1 protein measurement · score 0.32
protein measurement · score 0.30
blood protein measurement · score 0.29
breast adenocarcinoma · score 0.26
cerebrospinal fluid biomarker measurement · score 0.25
serum amyloid A protein measurement · score 0.24
endometrial cancer · score 0.23
cutaneous melanoma · score 0.22
hair colour measurement · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DJI8-F1	alphafold	PREDICTED	93.52	—

Amino-acid sequence (122 residues)

MKLLTGLVFC SLVLGVSSRS FFSFLGEAFD GARDMWRAYS DMREANYIGS DKYFHARGNY DAAKRGPGGA WAAEVITDAR ENIQRFFGHG AEDSLADQAA NEWGRSGKDP NHFRPAGLPE KY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards