Apelin receptor early endogenous ligand (APELA)

About Apelin receptor early endogenous ligand

Apelin receptor early endogenous ligand (APELA) is a protein from Homo sapiens identified by UniProt accession P0DMC3, 54 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Apelin receptor early endogenous ligand
UniProt accession	P0DMC3
Gene	APELA
Organism	Homo sapiens
Length	54 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

attention deficit hyperactivity disorder · score 0.28
glioblastoma multiforme · score 0.08
neoplasm · score 0.06
myocardial infarction · score 0.06
cancer · score 0.04
Ischemic stroke · score 0.04
atrial fibrillation · score 0.03
chronic obstructive pulmonary disease · score 0.03
preeclampsia · score 0.03
non-small cell lung carcinoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DMC3-F1	alphafold	PREDICTED	72.54	—

Amino-acid sequence (54 residues)

MRFQQFLFAF FIFIMSLLLI SGQRPVNLTM RRKLRKHNCL QRRCMPLHSR VPFP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards