Heterogeneous nuclear ribonucleoprotein C-like 4…

About Heterogeneous nuclear ribonucleoprotein C-like 4

Heterogeneous nuclear ribonucleoprotein C-like 4 (HNRNPCL4) is a protein from Homo sapiens identified by UniProt accession P0DMR1, 293 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Heterogeneous nuclear ribonucleoprotein C-like 4
UniProt accession	P0DMR1
Gene	HNRNPCL4
Organism	Homo sapiens
Length	293 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

MODY · score 0.05
hereditary hyperferritinemia with congenital cataracts · score 0.04
Juvenile cataract - microcornea - renal glucosuria · score 0.04
juvenile cataract-microcornea-renal glucosuria syndrome · score 0.04
islet cell adenomatosis · score 0.04
Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
exfoliation syndrome · score 0.03
granular corneal dystrophy type I · score 0.03
Cataract with Y-shaped suture opacities · score 0.03
Cataract-microcornea syndrome · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DMR1-F1	alphafold	PREDICTED	70.52	—

Amino-acid sequence (293 residues)

MASNVTNKMD PHSMNSRVFI GNLNTLVVKK SDVEAIFSKY GKIAGCSVHK GFAFVQYDKE KNARAAVAGE DGRMIASQVV DINLAAEPKV NRGNAGVKRS AAEMYGSSFD LDYNLQRDYY GGMYSFPARV PPPPPIALAV VPSKRQRISG NTSRRGKSGF NSKSGKRGSS KSGKLKGDDL QAIKQELTQI KQKVDSLLEN LEKIEKEHCK QGVEVKNAKS EEEQTSSSSK KDKTHVKMES EGGADDSVEE GDLLCDDDNE DQGDNQLELI KDDEKGAEEG EDDRDRANGQ DDS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Heterogeneous nuclear ribonucleoprotein C-like 4 (HNRNPCL4)