Cancer/testis antigen family 45 member A5 (CT45A5)

About Cancer/testis antigen family 45 member A5

Cancer/testis antigen family 45 member A5 (CT45A5) is a protein from Homo sapiens identified by UniProt accession P0DMU8, 189 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Cancer/testis antigen family 45 member A5
UniProt accession	P0DMU8
Gene	CT45A5
Organism	Homo sapiens
Length	189 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.29
hypertriglyceridemia 2 · score 0.08
cholesterol-ester transfer protein deficiency · score 0.08
thyroid hormone metabolism, abnormal, 2 · score 0.07
sitosterolemia · score 0.07
Combined hyperlipidemia · score 0.06
homozygous familial hypercholesterolemia · score 0.06
hypercholesterolemia, autosomal dominant, 3 · score 0.05
hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.05
hypercholesterolemia, autosomal dominant, type B · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DMU8-F1	alphafold	PREDICTED	68.92	—

Amino-acid sequence (189 residues)

MTDKTEKVAV DPETVFKRPR ECDSPSYQKR QRMALLARKQ GAGDSLIAGS AMSKEKKLMT GHAIPPSQLD SQIDDFTGFS KDGMMQKPGS NAPVGGNVTS SFSGDDLECR ETASSPKSQR EINADIKRKL VKELRCVGQK YEKIFEMLEG VQGPTAVRKR FFESIIKEAA RCMRRDFVKH LKKKLKRMI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards