Beta-defensin 130A (DEFB130A)

About Beta-defensin 130A

Beta-defensin 130A (DEFB130A) is a protein from Homo sapiens identified by UniProt accession P0DP74, 79 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Beta-defensin 130A
UniProt accession	P0DP74
Gene	DEFB130A
Organism	Homo sapiens
Length	79 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

gut microbiome measurement · score 0.29
Cystic Kidney Disease · score 0.23
neutrophil count · score 0.12
heel bone mineral density · score 0.08
benign prostatic hyperplasia · score 0.05
hypothyroidism · score 0.03
peak expiratory flow · score 0.02
bacterial disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DP74-F1	alphafold	PREDICTED	83.77	—

Amino-acid sequence (79 residues)

MKLHSLISVL LLFVTLIPKG KTGVIPGQKQ CIALKGVCRD KLCSTLDDTI GICNEGKKCC RRWWILEPYP TPVPKGKSP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards