About Chimeric ERCC6-PGBD3 protein
Chimeric ERCC6-PGBD3 protein (ERCC6) is a protein
from Homo sapiens identified by UniProt accession
P0DP91, 1061 residues long.
MolForge cross-references it against 0 known binders and
164 disease associations.
Target properties
| Protein name | Chimeric ERCC6-PGBD3 protein |
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| UniProt accession | P0DP91 |
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| Gene | ERCC6 |
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| Organism | Homo sapiens |
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| Length | 1061 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (164)
Diseases linked to this target (Open Targets).
- Cockayne syndrome type 2 · score 0.84
- cerebrooculofacioskeletal syndrome 1 · score 0.72
- UV-sensitive syndrome 1 · score 0.70
- Cockayne syndrome · score 0.69
- de Sanctis-Cacchione syndrome · score 0.69
- premature ovarian failure 11 · score 0.67
- UV-sensitive syndrome · score 0.62
- genetic disorder · score 0.54
- lung cancer · score 0.52
- Joubert syndrome and related disorders · score 0.51
Amino-acid sequence (1061 residues)
MPNEGIPHSS QTQEQDCLQS QPVSNNEEMA IKQESGGDGE VEEYLSFRSV GDGLSTSAVG CASAAPRRGP ALLHIDRHQI QAVEPSAQAL ELQGLGVDVY DQDVLEQGVL QQVDNAIHEA SRASQLVDVE KEYRSVLDDL TSCTTSLRQI NKIIEQLSPQ AATSRDINRK LDSVKRQKYN KEQQLKKITA KQKHLQAILG GAEVKIELDH ASLEEDAEPG PSSLGSMLMP VQETAWEELI RTGQMTPFGT QIPQKQEKKP RKIMLNEASG FEKYLADQAK LSFERKKQGC NKRAARKAPA PVTPPAPVQN KNKPNKKARV LSKKEERLKK HIKKLQKRAL QFQGKVGLPK ARRPWESDMR PEAEGDSEGE ESEYFPTEEE EEEEDDEVEG AEADLSGDGT DYELKPLPKG GKRQKKVPVQ EIDDDFFPSS GEEAEAASVG EGGGGGRKVG RYRDDGDEDY YKQRLSPKMP RTLSLHEITD LLETDDSIEA SAIVIQPPEN ATAPVSDEES GDEEGGTINN LPGSLLHTAA YLIQDGSDAE SDSDDPSYAP KDDSPDEVPS TFTVQQPPPS RRRKMTKILC KWKKADLTVQ PVAGRVTAPP NDFFTVMRTP TEILELFLDD EVIELIVKYS NLYACSKGVH LGLTSSEFKC FLGIIFLSGY VSVPRRRMFW EQRTDVHNVL VSAAMRRDRF ETIFSNLHVA DNANLDPVDK FSKLRPLISK LNERCMKFVP NETYFSFDEF MVPYFGRHGC KQFIRGKPIR FGYKFWCGAT CLGYICWFQP YQGKNPNTKH EEYGVGASLV LQFSEALTEA HPGQYHFVFN NFFTSIALLD KLSSMGHQAT GTVRKDHIDR VPLESDVALK KKERGTFDYR IDGKGNIVCR WNDNSVVTVA SSGAGIHPLC LVSRYSQKLK KKIQVQQPNM IKVYNQFMGG VDRADENIDK YRASIRGKKW YSSPLLFCFE LVLQNAWQLH KTYDEKPVDF LEFRRRVVCH YLETHGHPPE PGQKGRPQKR NIDSRYDGIN HVIVKQGKQT RCAECHKNTT FRCEKCDVAL HVKCSVEYHT E
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