About V-set and immunoglobulin domain-containing protein 8
V-set and immunoglobulin domain-containing protein 8 (VSIG8) is a protein
from Homo sapiens identified by UniProt accession
P0DPA2, 414 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | V-set and immunoglobulin domain-containing protein 8 |
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| UniProt accession | P0DPA2 |
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| Gene | VSIG8 |
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| Organism | Homo sapiens |
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| Length | 414 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.06
- hypertrophic cardiomyopathy · score 0.05
- platelet component distribution width · score 0.05
- Arrhythmogenic right ventricular dysplasia · score 0.05
- Romano-Ward syndrome · score 0.05
- Brugada syndrome · score 0.05
- cortical surface area measurement · score 0.05
- brain measurement · score 0.05
- Familial short QT syndrome · score 0.04
- monocyte count · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DPA2-F1 | alphafold | PREDICTED | 69.05 | — |
Amino-acid sequence (414 residues)
MRVGGAFHLL LVCLSPALLS AVRINGDGQE VLYLAEGDNV RLGCPYVLDP EDYGPNGLDI EWMQVNSDPA HHRENVFLSY QDKRINHGSL PHLQQRVRFA ASDPSQYDAS INLMNLQVSD TATYECRVKK TTMATRKVIV TVQARPAVPM CWTEGHMTYG NDVVLKCYAS GGSQPLSYKW AKISGHHYPY RAGSYTSQHS YHSELSYQES FHSSINQGLN NGDLVLKDIS RADDGLYQCT VANNVGYSVC VVEVKVSDSR RIGVIIGIVL GSLLALGCLA VGIWGLVCCC CGGSGAGGAR GAFGYGNGGG VGGGACGDLA SEIREDAVAP GCKASGRGSR VTHLLGYPTQ NVSRSLRRKY APPPCGGPED VALAPCTAAA ACEAGPSPVY VKVKSAEPAD CAEGPVQCKN GLLV
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