About Endothelin-converting enzyme 2
Endothelin-converting enzyme 2 (ECE2) is a protein
from Homo sapiens identified by UniProt accession
P0DPD6, 811 residues long.
MolForge cross-references it against 0 known binders and
63 disease associations.
Target properties
| Protein name | Endothelin-converting enzyme 2 |
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| UniProt accession | P0DPD6 |
|---|
| Gene | ECE2 |
|---|
| Organism | Homo sapiens |
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| Length | 811 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (63)
Diseases linked to this target (Open Targets).
- body mass index · score 0.26
- ovarian cancer · score 0.25
- glioblastoma multiforme · score 0.25
- daytime rest measurement · score 0.22
- appendicular lean mass · score 0.21
- age at menarche · score 0.21
- Immature Reticulocyte Fraction Measurement · score 0.18
- excessive daytime sleepiness measurement · score 0.18
- diet measurement · score 0.18
- lean body mass · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DPD6-F1 | alphafold | PREDICTED | 87.09 | — |
Amino-acid sequence (811 residues)
MNVALQELGA GSNMVEYKRA TLRDEDAPET PVEGGASPDA MEVGKGASPF SPGPSPGMTP GTPRSSGLFW RVTCPHLRSI SGLCSRTMVG FQKGTRQLLG SRTQLELVLA GASLLLAALL LGCLVALGVQ YHRDPSHSTC LTEACIRVAG KILESLDRGV SPCEDFYQFS CGGWIRRNPL PDGRSRWNTF NSLWDQNQAI LKHLLENTTF NSSSEAEQKT QRFYLSCLQV ERIEELGAQP LRDLIEKIGG WNITGPWDQD NFMEVLKAVA GTYRATPFFT VYISADSKSS NSNVIQVDQS GLFLPSRDYY LNRTANEKVL TAYLDYMEEL GMLLGGRPTS TREQMQQVLE LEIQLANITV PQDQRRDEEK IYHKMSISEL QALAPSMDWL EFLSFLLSPL ELSDSEPVVV YGMDYLQQVS ELINRTEPSI LNNYLIWNLV QKTTSSLDRR FESAQEKLLE TLYGTKKSCV PRWQTCISNT DDALGFALGS LFVKATFDRQ SKEIAEGMIS EIRTAFEEAL GQLVWMDEKT RQAAKEKADA IYDMIGFPDF ILEPKELDDV YDGYEISEDS FFQNMLNLYN FSAKVMADQL RKPPSRDQWS MTPQTVNAYY LPTKNEIVFP AGILQAPFYA RNHPKALNFG GIGVVMGHEL THAFDDQGRE YDKEGNLRPW WQNESLAAFR NHTACMEEQY NQYQVNGERL NGRQTLGENI ADNGGLKAAY NAYKAWLRKH GEEQQLPAVG LTNHQLFFVG FAQVWCSVRT PESSHEGLVT DPHSPARFRV LGTLSNSRDF LRHFGCPVGS PMNPGQLCEV W
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