About EEF1AKMT4-ECE2 readthrough transcript protein
EEF1AKMT4-ECE2 readthrough transcript protein (EEF1AKMT4-ECE2) is a protein
from Homo sapiens identified by UniProt accession
P0DPD8, 883 residues long.
MolForge cross-references it against 0 known binders and
27 disease associations.
Target properties
| Protein name | EEF1AKMT4-ECE2 readthrough transcript protein |
|---|
| UniProt accession | P0DPD8 |
|---|
| Gene | EEF1AKMT4-ECE2 |
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| Organism | Homo sapiens |
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| Length | 883 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (27)
Diseases linked to this target (Open Targets).
- cortical thickness · score 0.17
- mathematical ability · score 0.16
- neuroimaging measurement · score 0.13
- brain volume measurement · score 0.13
- lean body mass · score 0.07
- body mass index · score 0.07
- fat body mass · score 0.06
- whole body water mass · score 0.05
- base metabolic rate measurement · score 0.05
- Immature Reticulocyte Fraction Measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DPD8-F1 | alphafold | PREDICTED | 91.22 | — |
Amino-acid sequence (883 residues)
MASPGAGRAP PELPERNCGY REVEYWDQRY QGAADSAPYD WFGDFSSFRA LLEPELRPED RILVLGCGNS ALSYELFLGG FPNVTSVDYS SVVVAAMQAR HAHVPQLRWE TMDVRKLDFP SASFDVVLEK GTLDALLAGE RDPWTVSSEG VHTVDQVLSE VGFQKGTRQL LGSRTQLELV LAGASLLLAA LLLGCLVALG VQYHRDPSHS TCLTEACIRV AGKILESLDR GVSPCEDFYQ FSCGGWIRRN PLPDGRSRWN TFNSLWDQNQ AILKHLLENT TFNSSSEAEQ KTQRFYLSCL QVERIEELGA QPLRDLIEKI GGWNITGPWD QDNFMEVLKA VAGTYRATPF FTVYISADSK SSNSNVIQVD QSGLFLPSRD YYLNRTANEK VLTAYLDYME ELGMLLGGRP TSTREQMQQV LELEIQLANI TVPQDQRRDE EKIYHKMSIS ELQALAPSMD WLEFLSFLLS PLELSDSEPV VVYGMDYLQQ VSELINRTEP SILNNYLIWN LVQKTTSSLD RRFESAQEKL LETLYGTKKS CVPRWQTCIS NTDDALGFAL GSLFVKATFD RQSKEIAEGM ISEIRTAFEE ALGQLVWMDE KTRQAAKEKA DAIYDMIGFP DFILEPKELD DVYDGYEISE DSFFQNMLNL YNFSAKVMAD QLRKPPSRDQ WSMTPQTVNA YYLPTKNEIV FPAGILQAPF YARNHPKALN FGGIGVVMGH ELTHAFDDQG REYDKEGNLR PWWQNESLAA FRNHTACMEE QYNQYQVNGE RLNGRQTLGE NIADNGGLKA AYNAYKAWLR KHGEEQQLPA VGLTNHQLFF VGFAQVWCSV RTPESSHEGL VTDPHSPARF RVLGTLSNSR DFLRHFGCPV GSPMNPGQLC EVW
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