Tubulin alpha-3D chain (TUBA3D)

About Tubulin alpha-3D chain

Tubulin alpha-3D chain (TUBA3D) is a protein from Homo sapiens identified by UniProt accession P0DPH8, 450 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Tubulin alpha-3D chain
UniProt accession	P0DPH8
Gene	TUBA3D
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

viral disease · score 0.46
keratoconus · score 0.42
arterial stiffness measurement · score 0.20
bulimia nervosa · score 0.07
adolescent idiopathic scoliosis · score 0.04
Kleine-Levin Syndrome · score 0.04
colorectal adenocarcinoma · score 0.04
pancreatic adenocarcinoma · score 0.04
Renal glucosuria · score 0.03
severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DPH8-F1	alphafold	PREDICTED	91.34	—

Amino-acid sequence (450 residues)

MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK HVPRAVFVDL EPTVVDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIVDLVLD RIRKLADLCT GLQGFLIFHS FGGGTGSGFA SLLMERLSVD YGKKSKLEFA IYPAPQVSTA VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL IGQIVSSITA SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN QMVKCDPRHG KYMACCMLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE AREDLAALEK DYEEVGVDSV EAEAEEGEEY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards