Notch homolog 2 N-terminal-like protein B (NOTCH2NLB)

About Notch homolog 2 N-terminal-like protein B

Notch homolog 2 N-terminal-like protein B (NOTCH2NLB) is a protein from Homo sapiens identified by UniProt accession P0DPK3, 275 residues long. MolForge cross-references it against 0 known binders and 5 disease associations.

Target properties

Protein name	Notch homolog 2 N-terminal-like protein B
UniProt accession	P0DPK3
Gene	NOTCH2NLB
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (5)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.02
neuronal intranuclear inclusion disease · score 0.01
nervous system disease · score 0.01
Microcephaly · score 0.00
neurodegenerative disease · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DPK3-F1	alphafold	PREDICTED	85.54	—

Amino-acid sequence (275 residues)

MPALRPALLW ALLALWLCCA TPAHALQCRD GYEPCVNEGM CVTYHNGTGY CKCPEGFLGE YCQHRDPCEK NRCQNGGTCV AQAMLGKATC RCASGFTGED CQYSTSHPCF VSRPCLNGGT CHMLSRDTYE CTCQVGFTGK ECQWTDACLS HPCANGSTCT TVANQFSCKC LTGFTGQKCE TDVNECDIPG HCQHGGICLN LPGSYQCQCL QGFTGQYCDS LYVPCAPSPC VNGGTCRQTG DFTFECNCLP ETVRRGTELW ERDREVWNGK EHDEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards