Notch homolog 2 N-terminal-like protein C (NOTCH2NLC)

About Notch homolog 2 N-terminal-like protein C

Notch homolog 2 N-terminal-like protein C (NOTCH2NLC) is a protein from Homo sapiens identified by UniProt accession P0DPK4, 293 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.

Target properties

Protein name	Notch homolog 2 N-terminal-like protein C
UniProt accession	P0DPK4
Gene	NOTCH2NLC
Organism	Homo sapiens
Length	293 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (33)

Diseases linked to this target (Open Targets).

neuronal intranuclear inclusion disease · score 0.50
oculopharyngodistal myopathy · score 0.45
tremor, hereditary essential, 6 · score 0.45
fragile X-associated tremor/ataxia syndrome · score 0.01
allergic rhinitis · score 0.01
myotonic dystrophy type 2 · score 0.01
distal hereditary motor neuropathy · score 0.00
focal segmental glomerulosclerosis · score 0.00
Retinal dystrophy · score 0.00
Leukoencephalopathy · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DPK4-F1	alphafold	PREDICTED	80.79	—

Amino-acid sequence (293 residues)

MWICPGGGGG GGGGGGGGDR EDARPAPLCC GRCWRSGCAA RPPRMCRDGY EPCVNEGMCV TYHNGTGYCK CPEGFLGEYC QHRDPCEKNR CQNGGTCVAQ AMLGKATCRC ASGFTGEDCQ YSTSHPCFVS RPCLNGGTCH MLSRDTYECT CQVGFTGKEC QWTDACLSHP CANGSTCTTV ANQFSCKCLT GFTGQKCETD VNECDIPGHC QHGGTCLNLP GSYQCQCLQG FTGQYCDSLY VPCAPSPCVN GGTCRQTGDF TFECNCLPET VRRGTELWER DREVWNGKEH DEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards