About UDP-glucuronosyltransferase 2A1
UDP-glucuronosyltransferase 2A1 (UGT2A1) is a protein
from Homo sapiens identified by UniProt accession
P0DTE4, 527 residues long.
MolForge cross-references it against 0 known binders and
28 disease associations.
Target properties
| Protein name | UDP-glucuronosyltransferase 2A1 |
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| UniProt accession | P0DTE4 |
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| Gene | UGT2A1 |
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| Organism | Homo sapiens |
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| Length | 527 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (28)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- smoking behavior · score 0.33
- cutaneous melanoma · score 0.18
- lung adenocarcinoma · score 0.17
- glioblastoma multiforme · score 0.17
- uterine fibroid · score 0.13
- squamous cell lung carcinoma · score 0.10
- attention deficit-hyperactivity disorder 8 · score 0.07
- attention deficit hyperactivity disorder · score 0.07
- schizophrenia 15 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DTE4-F1 | alphafold | PREDICTED | 88.40 | — |
Amino-acid sequence (527 residues)
MLNNLLLFSL QISLIGTTLG GNVLIWPMEG SHWLNVKIII DELIKKEHNV TVLVASGALF ITPTSNPSLT FEIYKVPFGK ERIEGVIKDF VLTWLENRPS PSTIWRFYQE MAKVIKDFHM VSQEICDGVL KNQQLMAKLK KSKFEVLVSD PVFPCGDIVA LKLGIPFMYS LRFSPASTVE KHCGKVPYPP SYVPAVLSEL TDQMSFTDRI RNFISYHLQD YMFETLWKSW DSYYSKALGG LLLCCPGWSA VADLGSLQPL LPGFKRFSRL SLHCSWDYRL PAGRPTTLCE TMGKAEIWLI RTYWDFEFPR PYLPNFEFVG GLHCKPAKPL PKVLWRYKGK KPATLGNNTQ LFDWIPQNDL LGHPKTKAFI THGGTNGIYE AIYHGVPMVG VPMFADQPDN IAHMKAKGAA VEVNLNTMTS VDLLSALRTV INEPSYKENA MRLSRIHHDQ PVKPLDRAVF WIEFVMRHKG AKHLRVAAHD LTWFQYHSLD VIGFLLVCVT TAIFLVIQCC LFSCQKFGKI GKKKKRE
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