UDP-glucuronosyltransferase 2A2 (UGT2A2)

About UDP-glucuronosyltransferase 2A2

UDP-glucuronosyltransferase 2A2 (UGT2A2) is a protein from Homo sapiens identified by UniProt accession P0DTE5, 536 residues long. MolForge cross-references it against 0 known binders and 10 disease associations.

Target properties

Protein name	UDP-glucuronosyltransferase 2A2
UniProt accession	P0DTE5
Gene	UGT2A2
Organism	Homo sapiens
Length	536 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (10)

Diseases linked to this target (Open Targets).

smoking behavior · score 0.12
uterine fibroid · score 0.04
C-X-C motif chemokine 10 measurement · score 0.03
AR-C124910XX measurement · score 0.02
total cholesterol measurement · score 0.02
low density lipoprotein cholesterol measurement · score 0.02
pulse pressure measurement · score 0.02
COVID-19 · score 0.01
Anosmia · score 0.01
cancer · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DTE5-F1	alphafold	PREDICTED	92.55	—

Amino-acid sequence (536 residues)

MVSIRDFTMP KKFVQMLVFN LTLTEVVLSG NVLIWPTDGS HWLNIKIILE ELIQRNHNVT VLASSATLFI NSNPDSPVNF EVIPVSYKKS NIDSLIEHMI MLWIDHRPTP LTIWAFYKEL GKLLDTFFQI NIQLCDGVLK NPKLMARLQK GGFDVLVADP VTICGDLVAL KLGIPFMYTL RFSPASTVER HCGKIPAPVS YVPAALSELT DQMTFGERIK NTISYSLQDY IFQSYWGEWN SYYSKILGRP TTLCETMGKA EIWLIRTYWD FEFPRPYLPN FEFVGGLHCK PAKPLPKEME EFIQSSGKNG VVVFSLGSMV KNLTEEKANL IASALAQIPQ KVLWRYKGKK PATLGNNTQL FDWIPQNDLL GHPKTKAFIT HGGTNGIYEA IYHGVPMVGV PMFADQPDNI AHMKAKGAAV EVNLNTMTSV DLLSALRTVI NEPSYKENAM RLSRIHHDQP VKPLDRAVFW IEFVMRHKGA KHLRVAAHDL TWFQYHSLDV IGFLLVCVTT AIFLVIQCCL FSCQKFGKIG KKKKRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards