Zinc finger TRAF-type-containing protein 1 (ZFTRAF1)

About Zinc finger TRAF-type-containing protein 1

Zinc finger TRAF-type-containing protein 1 (ZFTRAF1) is a protein from Homo sapiens identified by UniProt accession P0DTL6, 404 residues long. MolForge cross-references it against 0 known binders and 52 disease associations.

Target properties

Protein name	Zinc finger TRAF-type-containing protein 1
UniProt accession	P0DTL6
Gene	ZFTRAF1
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (52)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with hypotonia and gross motor and speech delay · score 0.44
sex hormone-binding globulin measurement · score 0.25
self reported educational attainment · score 0.18
age at first birth measurement · score 0.16
mathematical ability · score 0.15
testosterone measurement · score 0.15
serum alanine aminotransferase measurement · score 0.13
intelligence · score 0.11
vital capacity · score 0.09
cognitive function measurement · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P0DTL6-F1	alphafold	PREDICTED	80.06	—

Amino-acid sequence (404 residues)

MSGAEEAGGG GPAAGPAGSV PAGVGVGVGA GPGAAAGQAA AAALGEAAGP GLPDEAGLAG ARQLQLQEAA GDPDAPPKKR LRAAEAAEAA AAAAAAGSGK LEERLYSVLC CTVCLDLPKA SVYQCTNGHL MCAGCFIHLL ADARLKEEQA TCPNCRCEIS KSLCCRNLAV EKAVSELPSE CGFCLRQFPR SLLERHQKEE CQDRVTQCKY KRIGCPWHGP FHELTVHEAA CAHPTKTGSE LMEILDGMDQ SHRKEMQLYN SIFSLLSFEK IGYTEVQFRP YRTDDFITRL YYETPRFTVL NQTWVLKARV NDSERNPNLS CKRTLSFQLL LKSKVTAPLE CSFLLLKGPY DDVRISPVIY HFVFTNESNE TDYVPLPIID SVECNKLLAA KNINLRLFLF QIQK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards