Zinc finger protein GLI4 (GLI4)

About Zinc finger protein GLI4

Zinc finger protein GLI4 (GLI4) is a protein from Homo sapiens identified by UniProt accession P10075, 376 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.

Target properties

Protein name	Zinc finger protein GLI4
UniProt accession	P10075
Gene	GLI4
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (20)

Diseases linked to this target (Open Targets).

body height · score 0.33
mean corpuscular volume · score 0.31
mean corpuscular hemoglobin concentration · score 0.26
appendicular lean mass · score 0.20
BMI-adjusted hip circumference · score 0.18
cortical thickness · score 0.12
erythrocyte count · score 0.11
mean reticulocyte volume · score 0.03
COVID-19 · score 0.02
Dravet syndrome · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10075-F1	alphafold	PREDICTED	64.75	—

Amino-acid sequence (376 residues)

MAALGDIQES PSVPSPVSLS SPGTPGTQHH EPQLHLHGHQ HGSPGSSPKV LSQPSDLDLQ DVEEVEIGRD TFWPDSEPKP EQAPRSPGSQ APDEGAGGAL RSLLRSLPRR ARCSAGFGPE SSAERPAGQP PGAVPCAQPR GAWRVTLVQQ AAAGPEGAPE RAAELGVNFG RSRQGSARGA KPHRCEACGK SFKYNSLLLK HQRIHTGEKP YACHECGKRF RGWSGFIQHH RIHTGEKPYE CGQCGRAFSH SSHFTQHLRI HNGEKPYKCG ECGQAFSQSS NLVRHQRLHT GEKPYACSQC GKAFIWSSVL IEHQRIHTGE KPYECSDCGK AFRGRSHFFR HLRTHTGEKP FACGACGKAF GQSSQLIQHQ RVHYRE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards