Calcitonin gene-related peptide 2 (CALCB)

About Calcitonin gene-related peptide 2

Calcitonin gene-related peptide 2 (CALCB) is a protein from Homo sapiens identified by UniProt accession P10092, 127 residues long. MolForge cross-references it against 0 known binders and 224 disease associations.

Target properties

Protein name	Calcitonin gene-related peptide 2
UniProt accession	P10092
Gene	CALCB
Organism	Homo sapiens
Length	127 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (224)

Diseases linked to this target (Open Targets).

migraine disorder · score 0.68
pain · score 0.38
trigeminal neuralgia · score 0.37
neuralgia · score 0.37
diverticular disease · score 0.28
bowel opening frequency · score 0.28
vitamin D measurement · score 0.27
diverticulitis · score 0.25
BMI-adjusted hip circumference · score 0.21
lean body mass · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10092-F1	alphafold	PREDICTED	71.18	—

Amino-acid sequence (127 residues)

MGFRKFSPFL ALSILVLYQA GSLQAAPFRS ALESSPDPAT LSKEDARLLL AALVQDYVQM KASELKQEQE TQGSSSAAQK RACNTATCVT HRLAGLLSRS GGMVKSNFVP TNVGSKAFGR RRRDLQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards