About Granzyme B
Granzyme B (GZMB) is a protein
from Homo sapiens identified by UniProt accession
P10144, 247 residues long.
MolForge cross-references it against 0 known binders and
714 disease associations.
Target properties
| Protein name | Granzyme B |
|---|
| UniProt accession | P10144 |
|---|
| Gene | GZMB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 247 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (714)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.40
- Vitiligo · score 0.37
- glioblastoma multiforme · score 0.27
- head and neck squamous cell carcinoma · score 0.24
- lung adenocarcinoma · score 0.19
- gastric adenocarcinoma · score 0.18
- acute myeloid leukemia · score 0.14
- neoplasm · score 0.12
- Rheumatoid arthritis · score 0.11
- interleukin 10 measurement · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10144-F1 | alphafold | PREDICTED | 92.41 | — |
Amino-acid sequence (247 residues)
MQPILLLLAF LLLPRADAGE IIGGHEAKPH SRPYMAYLMI WDQKSLKRCG GFLIRDDFVL TAAHCWGSSI NVTLGAHNIK EQEPTQQFIP VKRPIPHPAY NPKNFSNDIM LLQLERKAKR TRAVQPLRLP SNKAQVKPGQ TCSVAGWGQT APLGKHSHTL QEVKMTVQED RKCESDLRHY YDSTIELCVG DPEIKKTSFK GDSGGPLVCN KVAQGIVSYG RNNGMPPRAC TKVSSFVHWI KKTMKRY
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