About Non-secretory ribonuclease
Non-secretory ribonuclease (RNASE2) is a protein
from Homo sapiens identified by UniProt accession
P10153, 161 residues long.
MolForge cross-references it against 0 known binders and
165 disease associations.
Target properties
| Protein name | Non-secretory ribonuclease |
|---|
| UniProt accession | P10153 |
|---|
| Gene | RNASE2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 161 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (165)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.31
- eosinophil count · score 0.12
- Systemic lupus erythematosus · score 0.06
- eosinophil cationic protein measurement · score 0.05
- osteosarcoma · score 0.04
- axial length measurement · score 0.03
- Crohn's disease · score 0.03
- Bartsocas-Papas syndrome 1 · score 0.03
- nose morphology measurement · score 0.03
- hepatocellular carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10153-F1 | alphafold | PREDICTED | 91.22 | — |
Amino-acid sequence (161 residues)
MVPKLFTSQI CLLLLLGLLA VEGSLHVKPP QFTWAQWFET QHINMTSQQC TNAMQVINNY QRRCKNQNTF LLTTFANVVN VCGNPNMTCP SNKTRKNCHH SGSQVPLIHC NLTTPSPQNI SNCRYAQTPA NMFYIVACDN RDQRRDPPQY PVVPVHLDRI I
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