RNA-binding protein RO60 (RO60)

About RNA-binding protein RO60

RNA-binding protein RO60 (RO60) is a protein from Homo sapiens identified by UniProt accession P10155, 538 residues long. MolForge cross-references it against 0 known binders and 161 disease associations.

Target properties

Protein name	RNA-binding protein RO60
UniProt accession	P10155
Gene	RO60
Organism	Homo sapiens
Length	538 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (161)

Diseases linked to this target (Open Targets).

body mass index · score 0.24
Systemic lupus erythematosus · score 0.10
lymphocyte count · score 0.09
autosomal systemic lupus erythematosus type 16 · score 0.08
autoimmune disease · score 0.07
peripheral vascular disease · score 0.07
systemic scleroderma · score 0.07
chronotype measurement · score 0.07
C1Q deficiency 1 · score 0.07
Rheumatoid arthritis · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10155-F1	alphafold	PREDICTED	93.28	—

Amino-acid sequence (538 residues)

MEESVNQMQP LNEKQIANSQ DGYVWQVTDM NRLHRFLCFG SEGGTYYIKE QKLGLENAEA LIRLIEDGRG CEVIQEIKSF SQEGRTTKQE PMLFALAICS QCSDISTKQA AFKAVSEVCR IPTHLFTFIQ FKKDLKESMK CGMWGRALRK AIADWYNEKG GMALALAVTK YKQRNGWSHK DLLRLSHLKP SSEGLAIVTK YITKGWKEVH ELYKEKALSV ETEKLLKYLE AVEKVKRTRD ELEVIHLIEE HRLVREHLLT NHLKSKEVWK ALLQEMPLTA LLRNLGKMTA NSVLEPGNSE VSLVCEKLCN EKLLKKARIH PFHILIALET YKTGHGLRGK LKWRPDEEIL KALDAAFYKT FKTVEPTGKR FLLAVDVSAS MNQRVLGSIL NASTVAAAMC MVVTRTEKDS YVVAFSDEMV PCPVTTDMTL QQVLMAMSQI PAGGTDCSLP MIWAQKTNTP ADVFIVFTDN ETFAGGVHPA IALREYRKKM DIPAKLIVCG MTSNGFTIAD PDDRGMLDMC GFDTGALDVI RNFTLDMI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards