About Cytochrome c oxidase subunit 8A, mitochondrial
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) is a protein
from Homo sapiens identified by UniProt accession
P10176, 69 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Cytochrome c oxidase subunit 8A, mitochondrial |
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| UniProt accession | P10176 |
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| Gene | COX8A |
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| Organism | Homo sapiens |
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| Length | 69 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (109)
Diseases linked to this target (Open Targets).
- mitochondrial complex 4 deficiency, nuclear type 15 · score 0.37
- Isolated cytochrome C oxidase deficiency · score 0.37
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.36
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.36
- neurodegenerative disease · score 0.35
- neuroinflammatory disorder · score 0.27
- head and neck squamous cell carcinoma · score 0.19
- urinary bladder cancer · score 0.12
- Familial exudative vitreoretinopathy · score 0.05
- Familial drusen · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10176-F1 | alphafold | PREDICTED | 85.81 | — |
Amino-acid sequence (69 residues)
MSVLTPLLLR GLTGSARRLP VPRAKIHSLP PEGKLGIMEL AVGLTSCFVT FLLPAGWILS HLETYRRPE
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