About Transcriptional activator Myb
Transcriptional activator Myb (MYB) is a protein
from Homo sapiens identified by UniProt accession
P10242, 640 residues long.
MolForge cross-references it against 0 known binders and
927 disease associations.
Target properties
| Protein name | Transcriptional activator Myb |
|---|
| UniProt accession | P10242 |
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| Gene | MYB |
|---|
| Organism | Homo sapiens |
|---|
| Length | 640 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (927)
Diseases linked to this target (Open Targets).
- neutrophil count · score 0.48
- basophil count · score 0.48
- leukocyte count · score 0.48
- mean platelet volume · score 0.47
- monocyte count · score 0.43
- lymphocyte percentage of leukocytes · score 0.42
- neutrophil percentage of leukocytes · score 0.42
- erythrocyte count · score 0.39
- mean reticulocyte volume · score 0.38
- platelet crit · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10242-F1 | alphafold | PREDICTED | 58.07 | — |
Amino-acid sequence (640 residues)
MARRPRHSIY SSDEDDEDFE MCDHDYDGLL PKSGKRHLGK TRWTREEDEK LKKLVEQNGT DDWKVIANYL PNRTDVQCQH RWQKVLNPEL IKGPWTKEED QRVIELVQKY GPKRWSVIAK HLKGRIGKQC RERWHNHLNP EVKKTSWTEE EDRIIYQAHK RLGNRWAEIA KLLPGRTDNA IKNHWNSTMR RKVEQEGYLQ ESSKASQPAV ATSFQKNSHL MGFAQAPPTA QLPATGQPTV NNDYSYYHIS EAQNVSSHVP YPVALHVNIV NVPQPAAAAI QRHYNDEDPE KEKRIKELEL LLMSTENELK GQQVLPTQNH TCSYPGWHST TIADHTRPHG DSAPVSCLGE HHSTPSLPAD PGSLPEESAS PARCMIVHQG TILDNVKNLL EFAETLQFID SFLNTSSNHE NSDLEMPSLT STPLIGHKLT VTTPFHRDQT VKTQKENTVF RTPAIKRSIL ESSPRTPTPF KHALAAQEIK YGPLKMLPQT PSHLVEDLQD VIKQESDESG IVAEFQENGP PLLKKIKQEV ESPTDKSGNF FCSHHWEGDS LNTQLFTQTS PVADAPNILT SSVLMAPASE DEDNVLKAFT VPKNRSLASP LQPCSSTWEP ASCGKMEEQM TSSSQARKYV NAFSARTLVM
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