About Myb-related protein A
Myb-related protein A (MYBL1) is a protein
from Homo sapiens identified by UniProt accession
P10243, 752 residues long.
MolForge cross-references it against 0 known binders and
307 disease associations.
Target properties
| Protein name | Myb-related protein A |
|---|
| UniProt accession | P10243 |
|---|
| Gene | MYBL1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 752 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (307)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- body height · score 0.30
- cutaneous melanoma · score 0.15
- appendicular lean mass · score 0.12
- azoospermia · score 0.10
- neoplasm · score 0.10
- breast adenocarcinoma · score 0.09
- hepatocellular carcinoma · score 0.09
- partial chromosome Y deletion · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10243-F1 | alphafold | PREDICTED | 57.32 | — |
Amino-acid sequence (752 residues)
MAKRSRSEDE DDDLQYADHD YEVPQQKGLK KLWNRVKWTR DEDDKLKKLV EQHGTDDWTL IASHLQNRSD FQCQHRWQKV LNPELIKGPW TKEEDQRVIE LVQKYGPKRW SLIAKHLKGR IGKQCRERWH NHLNPEVKKS SWTEEEDRII YEAHKRLGNR WAEIAKLLPG RTDNSIKNHW NSTMRRKVEQ EGYLQDGIKS ERSSSKLQHK PCAAMDHMQT QNQFYIPVQI PGYQYVSPEG NCIEHVQPTS AFIQQPFIDE DPDKEKKIKE LEMLLMSAEN EVRRKRIPSQ PGSFSSWSGS FLMDDNMSNT LNSLDEHTSE FYSMDENQPV SAQQNSPTKF LAVEANAVLS SLQTIPEFAE TLELIESDPV AWSDVTSFDI SDAAASPIKS TPVKLMRIQH NEGAMECQFN VSLVLEGKKN TCNGGNSEAV PLTSPNIAKF STPPAILRKK RKMRVGHSPG SELRDGSLND GGNMALKHTP LKTLPFSPSQ FFNTCPGNEQ LNIENPSFTS TPICGQKALI TTPLHKETTP KDQKENVGFR TPTIRRSILG TTPRTPTPFK NALAAQEKKY GPLKIVSQPL AFLEEDIREV LKEETGTDLF LKEEDEPAYK SCKQENTASG KKVRKSLVLD NWEKEESGTQ LLTEDISDMQ SENRFTTSLL MIPLLEIHDN RCNLIPEKQD INSTNKTYTL TKKKPNPNTS KVVKLEKNLQ SNCEWETVVY GKTEDQLIMT EQARRYLSTY TATSSTSRAL IL
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