About Acrosin
Acrosin (ACR) is a protein
from Homo sapiens identified by UniProt accession
P10323, 421 residues long.
MolForge cross-references it against 0 known binders and
87 disease associations.
Target properties
| Protein name | Acrosin |
|---|
| UniProt accession | P10323 |
|---|
| Gene | ACR |
|---|
| Organism | Homo sapiens |
|---|
| Length | 421 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (87)
Diseases linked to this target (Open Targets).
- cutaneous melanoma · score 0.23
- squamous cell lung carcinoma · score 0.15
- glioblastoma multiforme · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- Male infertility with spermatogenesis disorder due to single gene mutation · score 0.07
- intelligence · score 0.06
- female infertility due to zona pellucida defect · score 0.06
- oocyte maturation defect 11 · score 0.06
- Rare genetic female infertility · score 0.06
- self reported educational attainment · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10323-F1 | alphafold | PREDICTED | 79.85 | — |
Amino-acid sequence (421 residues)
MVEMLPTAIL LVLAVSVVAK DNATCDGPCG LRFRQNPQGG VRIVGGKAAQ HGAWPWMVSL QIFTYNSHRY HTCGGSLLNS RWVLTAAHCF VGKNNVHDWR LVFGAKEITY GNNKPVKAPL QERYVEKIII HEKYNSATEG NDIALVEITP PISCGRFIGP GCLPHFKAGL PRGSQSCWVA GWGYIEEKAP RPSSILMEAR VDLIDLDLCN STQWYNGRVQ PTNVCAGYPV GKIDTCQGDS GGPLMCKDSK ESAYVVVGIT SWGVGCARAK RPGIYTATWP YLNWIASKIG SNALRMIQSA TPPPPTTRPP PIRPPFSHPI SAHLPWYFQP PPRPLPPRPP AAQPRPPPSP PPPPPPPASP LPPPPPPPPP TPSSTTKLPQ GLSFAKRLQQ LIEVLKGKTY SDGKNHYDME TTELPELTST S
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