About Serine/threonine-protein kinase A-Raf
Serine/threonine-protein kinase A-Raf (ARAF) is a protein
from Homo sapiens identified by UniProt accession
P10398, 606 residues long.
MolForge cross-references it against 0 known binders and
299 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase A-Raf |
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| UniProt accession | P10398 |
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| Gene | ARAF |
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| Organism | Homo sapiens |
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| Length | 606 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (299)
Diseases linked to this target (Open Targets).
- cancer · score 0.56
- hypertrophic cardiomyopathy · score 0.54
- Costello syndrome · score 0.54
- Noonan syndrome · score 0.54
- lung adenocarcinoma · score 0.46
- cutaneous melanoma · score 0.43
- papillary renal cell carcinoma · score 0.35
- breast adenocarcinoma · score 0.29
- low grade glioma · score 0.28
- endometrial cancer · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10398-F1 | alphafold | PREDICTED | 70.09 | — |
Amino-acid sequence (606 residues)
MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN RQQFYHSVQD LSGGSRQHEA PSNRPLNELL TPQGPSPRTQ HCDPEHFPFP APANAPLQRI RSTSTPNVHM VSTTAPMDSN LIQLTGQSFS TDAAGSRGGS DGTPRGSPSP ASVSSGRKSP HSKSPAEQRE RKSLADDKKK VKNLGYRDSG YYWEVPPSEV QLLKRIGTGS FGTVFRGRWH GDVAVKVLKV SQPTAEQAQA FKNEMQVLRK TRHVNILLFM GFMTRPGFAI ITQWCEGSSL YHHLHVADTR FDMVQLIDVA RQTAQGMDYL HAKNIIHRDL KSNNIFLHEG LTVKIGDFGL ATVKTRWSGA QPLEQPSGSV LWMAAEVIRM QDPNPYSFQS DVYAYGVVLY ELMTGSLPYS HIGCRDQIIF MVGRGYLSPD LSKISSNCPK AMRRLLSDCL KFQREERPLF PQILATIELL QRSLPKIERS ASEPSLHRTQ ADELPACLLS AARLVP
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