About Histone H1.4
Histone H1.4 (H1-4) is a protein
from Homo sapiens identified by UniProt accession
P10412, 219 residues long.
MolForge cross-references it against 0 known binders and
62 disease associations.
Target properties
| Protein name | Histone H1.4 |
|---|
| UniProt accession | P10412 |
|---|
| Gene | H1-4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 219 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (62)
Diseases linked to this target (Open Targets).
- Tatton-Brown-Rahman overgrowth syndrome · score 0.65
- genetic disorder · score 0.39
- syndromic intellectual disability · score 0.37
- auditory neuropathy · score 0.33
- Neurodevelopmental disorder · score 0.27
- multiple myeloma · score 0.26
- body height · score 0.18
- mean corpuscular hemoglobin · score 0.17
- liver iron measurement · score 0.14
- breast carcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10412-F1 | alphafold | PREDICTED | 64.72 | — |
Amino-acid sequence (219 residues)
MSETAPAAPA APAPAEKTPV KKKARKSAGA AKRKASGPPV SELITKAVAA SKERSGVSLA ALKKALAAAG YDVEKNNSRI KLGLKSLVSK GTLVQTKGTG ASGSFKLNKK AASGEAKPKA KKAGAAKAKK PAGAAKKPKK ATGAATPKKS AKKTPKKAKK PAAAAGAKKA KSPKKAKAAK PKKAPKSPAK AKAVKPKAAK PKTAKPKAAK PKKAAAKKK
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