S-arrestin (SAG)

About S-arrestin

S-arrestin (SAG) is a protein from Homo sapiens identified by UniProt accession P10523, 405 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.

Target properties

Protein name	S-arrestin
UniProt accession	P10523
Gene	SAG
Organism	Homo sapiens
Length	405 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (155)

Diseases linked to this target (Open Targets).

Oguchi disease · score 0.73
retinitis pigmentosa · score 0.71
bilirubin measurement · score 0.54
Retinal dystrophy · score 0.51
Posterior column ataxia - retinitis pigmentosa · score 0.41
lymphocyte count · score 0.38
congenital stationary night blindness · score 0.37
alkaline phosphatase measurement · score 0.37
calcium measurement · score 0.35
cone dystrophy · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10523-F1	alphafold	PREDICTED	85.04	—

Amino-acid sequence (405 residues)

MAASGKTSKS EPNHVIFKKI SRDKSVTIYL GNRDYIDHVS QVQPVDGVVL VDPDLVKGKK VYVTLTCAFR YGQEDIDVIG LTFRRDLYFS RVQVYPPVGA ASTPTKLQES LLKKLGSNTY PFLLTFPDYL PCSVMLQPAP QDSGKSCGVD FEVKAFATDS TDAEEDKIPK KSSVRLLIRK VQHAPLEMGP QPRAEAAWQF FMSDKPLHLA VSLNKEIYFH GEPIPVTVTV TNNTEKTVKK IKAFVEQVAN VVLYSSDYYV KPVAMEEAQE KVPPNSTLTK TLTLLPLLAN NRERRGIALD GKIKHEDTNL ASSTIIKEGI DRTVLGILVS YQIKVKLTVS GFLGELTSSE VATEVPFRLM HPQPEDPAKE SYQDANLVFE EFARHNLKDA GEAEEGKRDK NDVDE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards