Nuclear receptor subfamily 2 group F member 6 (NR2F6)

About Nuclear receptor subfamily 2 group F member 6

Nuclear receptor subfamily 2 group F member 6 (NR2F6) is a protein from Homo sapiens identified by UniProt accession P10588, 404 residues long. MolForge cross-references it against 0 known binders and 94 disease associations.

Target properties

Protein name	Nuclear receptor subfamily 2 group F member 6
UniProt accession	P10588
Gene	NR2F6
Organism	Homo sapiens
Length	404 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (94)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
sex hormone-binding globulin measurement · score 0.42
testosterone measurement · score 0.40
IGF-1 measurement · score 0.27
mean platelet volume · score 0.12
neoplasm · score 0.11
low density lipoprotein cholesterol measurement · score 0.09
hepatocellular carcinoma · score 0.08
melanoma · score 0.08
head and neck squamous cell carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10588-F1	alphafold	PREDICTED	77.34	—

Amino-acid sequence (404 residues)

MAMVTGGWGG PGGDTNGVDK AGGYPRAAED DSASPPGAAS DAEPGDEERP GLQVDCVVCG DKSSGKHYGV FTCEGCKSFF KRSIRRNLSY TCRSNRDCQI DQHHRNQCQY CRLKKCFRVG MRKEAVQRGR IPHSLPGAVA ASSGSPPGSA LAAVASGGDL FPGQPVSELI AQLLRAEPYP AAAGRFGAGG GAAGAVLGID NVCELAARLL FSTVEWARHA PFFPELPVAD QVALLRLSWS ELFVLNAAQA ALPLHTAPLL AAAGLHAAPM AAERAVAFMD QVRAFQEQVD KLGRLQVDSA EYGCLKAIAL FTPDACGLSD PAHVESLQEK AQVALTEYVR AQYPSQPQRF GRLLLRLPAL RAVPASLISQ LFFMRLVGKT PIETLIRDML LSGSTFNWPY GSGQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards