COUP transcription factor 1 (NR2F1)

About COUP transcription factor 1

COUP transcription factor 1 (NR2F1) is a protein from Homo sapiens identified by UniProt accession P10589, 423 residues long. MolForge cross-references it against 0 known binders and 206 disease associations.

Target properties

Protein name	COUP transcription factor 1
UniProt accession	P10589
Gene	NR2F1
Organism	Homo sapiens
Length	423 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (206)

Diseases linked to this target (Open Targets).

Bosch-Boonstra-Schaaf optic atrophy syndrome · score 0.79
Optic atrophy-intellectual disability syndrome · score 0.72
genetic disorder · score 0.52
neurodegenerative disease · score 0.50
mathematical ability · score 0.43
Neurodevelopmental delay · score 0.41
diet measurement · score 0.37
cortical thickness · score 0.36
self reported educational attainment · score 0.36
brain volume measurement · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10589-F1	alphafold	PREDICTED	75.28	—

Amino-acid sequence (423 residues)

MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQQAGSGAPH TPQTPGQPGA PATPGTAGDK GQGPPGSGQS QQHIECVVCG DKSSGKHYGQ FTCEGCKSFF KRSVRRNLTY TCRANRNCPI DQHHRNQCQY CRLKKCLKVG MRREAVQRGR MPPTQPNPGQ YALTNGDPLN GHCYLSGYIS LLLRAEPYPT SRYGSQCMQP NNIMGIENIC ELAARLLFSA VEWARNIPFF PDLQITDQVS LLRLTWSELF VLNAAQCSMP LHVAPLLAAA GLHASPMSAD RVVAFMDHIR IFQEQVEKLK ALHVDSAEYS CLKAIVLFTS DACGLSDAAH IESLQEKSQC ALEEYVRSQY PNQPSRFGKL LLRLPSLRTV SSSVIEQLFF VRLVGKTPIE TLIRDMLLSG SSFNWPYMSI QCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards