Thioredoxin (TXN)

About Thioredoxin

Thioredoxin (TXN) is a protein from Homo sapiens identified by UniProt accession P10599, 105 residues long. MolForge cross-references it against 0 known binders and 481 disease associations.

Target properties

Protein name	Thioredoxin
UniProt accession	P10599
Gene	TXN
Organism	Homo sapiens
Length	105 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (481)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
mean corpuscular hemoglobin · score 0.42
mean corpuscular volume · score 0.41
body height · score 0.40
mean corpuscular hemoglobin concentration · score 0.38
mean reticulocyte volume · score 0.35
sex hormone-binding globulin measurement · score 0.32
HbA1c measurement · score 0.29
urate measurement · score 0.29
breast adenocarcinoma · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P10599-F1	alphafold	PREDICTED	97.59	—

Amino-acid sequence (105 residues)

MVKQIESKTA FQEALDAAGD KLVVVDFSAT WCGPCKMIKP FFHSLSEKYS NVIFLEVDVD DCQDVASECE VKCMPTFQFF KKGQKVGEFS GANKEKLEAT INELV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards