About Transforming growth factor beta-3 proprotein
Transforming growth factor beta-3 proprotein (TGFB3) is a protein
from Homo sapiens identified by UniProt accession
P10600, 412 residues long.
MolForge cross-references it against 0 known binders and
580 disease associations.
Target properties
| Protein name | Transforming growth factor beta-3 proprotein |
|---|
| UniProt accession | P10600 |
|---|
| Gene | TGFB3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 412 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (580)
Diseases linked to this target (Open Targets).
- Rienhoff syndrome · score 0.74
- arrhythmogenic right ventricular dysplasia 1 · score 0.68
- familial thoracic aortic aneurysm and aortic dissection · score 0.64
- Loeys-Dietz syndrome · score 0.64
- myelodysplastic syndrome · score 0.55
- Rare disease with thoracic aortic aneurysm and aortic dissection · score 0.54
- anemia (phenotype) · score 0.48
- Beta-thalassemia · score 0.47
- Thalassemia · score 0.39
- emphysema · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P10600-F1 | alphafold | PREDICTED | 76.83 | — |
Amino-acid sequence (412 residues)
MKMHLQRALV VLALLNFATV SLSLSTCTTL DFGHIKKKRV EAIRGQILSK LRLTSPPEPT VMTHVPYQVL ALYNSTRELL EEMHGEREEG CTQENTESEY YAKEIHKFDM IQGLAEHNEL AVCPKGITSK VFRFNVSSVE KNRTNLFRAE FRVLRVPNPS SKRNEQRIEL FQILRPDEHI AKQRYIGGKN LPTRGTAEWL SFDVTDTVRE WLLRRESNLG LEISIHCPCH TFQPNGDILE NIHEVMEIKF KGVDNEDDHG RGDLGRLKKQ KDHHNPHLIL MMIPPHRLDN PGQGGQRKKR ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS
Explore Transforming growth factor beta-3 proprotein with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets